![]() ![]() In this report, we consider the relevant facts and context of Donald Trump’s push to overturn the 2020 election results in Georgia. 9 As recently as September 25, 2021, Trump returned to Georgia, stated that he had asked Governor Kemp for a second “special election,” and unleashed a barrage of attacks on him, the secretary of state, and others for not doing Trump’s bidding. The former president had publicly pressured and personally contacted several other officials in Georgia-including the governor, the attorney general, and the secretary of state’s chief investigator-about the election and how they might assist him in flipping the state’s electoral votes over to him even after the results had been duly certified. 8 At issue was not just Trump’s January 2 call to Raffensperger. 7 Two days later, Fulton County District Attorney Fani Willis announced the launch of a criminal investigation into Trump’s conduct vis-à-vis the election. On February 8, 2021, Raffensperger’s office opened a probe into Trump’s efforts to overturn his loss in the state. Trump’s entreaties to Raffensperger on the January 2 call, along with other steps he took to reverse his Georgia election loss, have exposed him and others involved to potential criminal liability in Georgia. But this was no mere transgression of norms alone. The transcript and audio file were reported by The Washington Post the following day, garnering widespread attention across a nation already aware of Trump’s refusal to accept the certified election results and assent to a peaceful transition of power. 6 As Trump apparently saw it, if Raffensperger’s office complied with his request and identified 11,780 votes for disqualification, Trump would be named the winner of the state’s presidential election (and presumably could use that development to seek a broader unraveling of the certified election results in other states confirming his defeat). 5 That number mattered to Trump for a single reason: It was exactly one more vote than the margin of Joe Biden’s 11,779-vote victory in the state. He urged, and ultimately threatened, Raffensperger to reverse the election outcome-culminating in a demand that Raffensperger “find 11,780 votes” that could be deemed fraudulent and tossed out. ![]() This is Trump media.” 4īut Trump did more than merely complain about the election and catalog disinformation. Throughout the roughly hour-long call, the former president repeatedly insisted that he had won the state of Georgia “by hundreds of thousands of votes.” 1 As purported evidence, Trump cited “rally size” and “political people” who he said assured him that “there’s no way they beat me.” 2 He cycled through a list of conspiracy theories to explain his loss, covering “3,000 pounds” of shredded ballots drop boxes “being delivered and delivered late” a particular “professional vote scammer and hustler” who Trump claimed destroyed no fewer than 18,000 of his votes and “the other thing, dead people.” 3 At one point, when Raffensperger responded to one of Trump’s false claims by cautioning him that “the problem you have with social media …people can say anything,” Trump answered: “Oh, this isn’t social media. Trump placed a call to Georgia’s Republican Secretary of State Brad Raffensperger. On Saturday, January 2, 2021, at around 3:00 p.m., former President Donald J. ![]()
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However, almost all drug candidates have failed in clinical trials over the past 30 years. ![]() We discuss the potential COUs for each biomarker.Īlzheimer’s disease (AD) research is entering a unique moment in which enormous information about the molecular basis of this disease is being translated into therapeutics. ![]() In this review, we summarize some of the pathological mechanisms implicated in the sporadic AD and highlight the data for several established and novel fluid biomarkers (including BACE1, TREM2, YKL-40, IP-10, neurogranin, SNAP-25, synaptotagmin, α-synuclein, TDP-43, ferritin, VILIP-1, and NF-L) associated with each mechanism. Several novel fluid biomarkers have been proposed, but their role in AD pathology and their use as AD biomarkers have yet to be validated. However, there is a need to better understand their potential for other COUs, as well as identify additional fluid biomarkers reflecting other aspects of AD pathophysiology. The core AD CSF biomarkers Aβ42, t-tau, and p-tau are recognized by research guidelines for their diagnostic utility and are being considered for qualification for subject selection in clinical trials. These COUs include, but are not limited to, subject/patient selection, assessment of disease state and/or prognosis, assessment of mechanism of action, dose optimization, drug response monitoring, efficacy maximization, and toxicity/adverse reactions identification and minimization. Biomarkers used in drug development programmes should be qualified for a specific context of use (COU). Fluid biomarkers measured in cerebrospinal fluid (CSF) or blood hold promise for enabling more effective drug development and establishing a more personalized medicine approach for AD diagnosis and treatment. The number of people living with AD is predicted to increase however, there are no disease-modifying therapies currently available and none have been successful in late-stage clinical trials. The purpose of this paper is to review the literature regarding the existing and emerging fluid biomarkers and to examine how fluid biomarkers have been incorporated into clinical trials.Īlzheimer’s disease (AD) is a progressive neurodegenerative disease with a complex and heterogeneous pathophysiology. Fluid biomarkers are important because they can provide information regarding the underlying biochemical processes that are occurring in the brain. Three biomarkers are neuroimaging measures - hippocampal atrophy measured by magnetic resonance imaging (MRI), amyloid uptake as measured by Pittsburg compound B positron emission tomography (PiB-PET), and decreased fluorodeoxyglucose (18F) uptake as measured by PET (FDG-PET) - and three are sampled from fluid sources - cerebrospinal fluid levels of amyloid β42 (Aβ42), total tau, and phosphorylated tau. Six biomarkers have now been included in diagnostic criteria for AD and are regularly incorporated into clinical trials. 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Awards will be presented for top overall and age group finishers. The Annual Kick It 5k takes place in early April and is the largest fundraiser for the Kosten Foundation. Registration includes race entry, commemorative race T-shirt and post race snacks. By submitting this review, I assure an objective honest, fair and unbiased opinion of this race. Once the 5th person registers, the pricing will change to the special $20 fee and the first 4 registrants will be refunded the additional amount paid. Kick It 5K Reviews, Versailles, Kentucky, RaceThread, Write a Review. Each additional person will register using the same name, paying the regular fee. ![]() Start and finish line across from the brewery. This years event will take place at Northwest High School on April 30th at 8:00AM. The race starts and ends at the Catawba Brewing South Slope tap room on Banks Ave. Thank you for your interest in the 11th Annual 'Kick It' 5K presented by Mayer Construction. To keep the tradition alive this year & raise needed. Team registration is simple, the first person to register will create a team name and pay the regular registration fee. Join us on October 29th for the 3rd Catawba Brewing White Zombie 5k Asheville’s only zombie race as well as a craft brew run. Kick in for Kids is a favorite, annual community event that supports the McKeown Boys & Girls Club. in United States at Hubie Gallagher Park - 15th Avenue & Filmore Street (3 Blocks off Tyler St) event logo. The top 5 times of each team will be combined and the fastest team will be presented an award. Kelly Kicking Cancer 5K and 1-Mile Fun Run. In addition to individual awards, there will also be an award for the fastest team! Teams of 5 or more members can register for a special registration fee of only $20. Our race features an easy paved course at beautiful Falling Springs Recreation Center that starts and finishes on the turf soccer field at the stadium. Places to stay near Fawn Creek are 638.21 ft² on average, with prices averaging 99 a night. Last years in-person and virtual event raised more. A portion of the proceeds will be used to provide scholarships for players in the club. The Kick It 5K is the Kosten Foundations largest fundraiser for pancreatic cancer research and support. ![]() This race will benefit the Bluegrass Soccer Club. Join us for the 2nd Annual KICK IT 5Kon Friday, April 13th at 7 pm at Falling Springs Recreation Center in Versailles. ![]() |
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